Frankenstein is part of a network of strange beings who work for an even stranger government organization: The Super Human Advanced Defense Executive, also known as S.H.A.D.E. Leading his new field team, The Creature Commandos, Frankenstein and company must fight against supernatural threats even more strange and dangerous than themselves.

This volume collects issues 1-6 of Frankenstein, Agent of S.H.A.D.E., part of the DC Comics—The New 52 event.